|
KMID : 1188320170110050648
|
|
Gut and Liver
2017 Volume.11 No. 5 p.648 ~ p.654
|
|
|
In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains
|
|
Chung Jun-Won
Kim Su-Young
Park Hee-Jung
Chung Chang-Su
Lee Hee-Woo
Lee Sun-Mi
Kim In-Ki
Pak Jhang-Ho
Lee Gin-Hyug
Jeong Jin-Yong
|
|
|
Abstract
|
|
|
Background/Aims: The increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. The aim of our study was to identify new drugs with anti-H. pylori activity.
Methods: We screened a small molecule library?the library of pharmacologically active compounds (LOPAC), which includes 1,280 pharmacologically active compounds?to identify inhibitors of H. pylori growth. The minimal inhibitory concentrations (MICs) of antibiotics against multidrug-resistant H. pylori strains were determined using the agar dilution method.
Results: We identified diphenyleneiodonium (DPI) as a novel anti-H. pylori agent. The MIC values for DPI were <0.03 μg/mL against all tested H. pylori strains. DPI also exhibited strong antibacterial activity against common gram-negative and gram-positive pathogenic bacteria.
Conclusions: DPI may be a candidate anti-H. pylori drug for future development.
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, Diphenyleneiodonium, Drug resistance, multiple, Anti-bacterial agents, Minimal inhibitory concentration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|